Guianvarch and co-workers confirmed by the preliminary pharmacological in-vivo models that sulphonamides emerge with a novel anticancer series. The derivatives with aromatic ring and aliphatic chain present in the nucleus have been shown to be critical for anticancer activity. Ĭandidates from amino-sulfonamide for designing novel anticancer agents emerge with promising effects. Topoisomerase II makes double strand breaks and passes double strand DNA through the nick to allow relaxation of over coiled DNA. They stimulate the topoisomerase II cleavable complex, which is a transient configuration of topoisomerase II on DNA in which topoisomerase II is covalently attached to DNA. It is also the cellular target for so many widely used anticancer agents currently in clinical use, such as anthracyclines, epipodophyllotoxins. It plays role in DNA metabolic processes where they involve in DNA replication, transcription, chromosome condensation and de-condensation, recombination etc. Topoisomerase II enzymes are capable of transferring one DNA double helix through a transient break in another DNA double helix. Certain molecular interactions between cells and the scaffolding that holds them in place cause them to become unstuck at the original tumor site, they become dislodged, move on and then reattach themselves at a new site. It has something to do with their adhesion properties. Scientists reported that they have discovered an important clue as to why cancer cells spread. This process itself is called metastasis, and the result is a serious condition that is very difficult to treat. When a tumor successfully spreads to other parts of the body and grows, invading and destroying other healthy tissues, it is said to have metastasized. Six characters of malignancy have been found in different researches, such as Cancer can affect people of all ages, and few are more common in children. Generally, cancer is treated with radiation therapy, chemotherapy and surgery. These factors cause cancerous mutations by damaging genes or combining with existing genetic faults. The chances of cancer increases with the tobacco use, dietary factors, lack of physical activity, certain infections, obesity, exposure to radiation and environmental pollutants. The cause of cancer is partially known with its diversity and complexity. There are about 2000 different known cancers which deliberately affects the human beings.

Cancer may spreads through lymphatic system or bloodstream. Cancer is medically known as malignant neoplasia which involves unregulated/uncontrolled cell growth forming malignant tumors.

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